Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

Role of microRNA-134 in the neuroprotective effects of propofol against oxygen-glucose deprivation and related mechanisms.

This study is to investigate the effects of propofol on primary hippocampal neurons under oxygen-glucose deprivation (OGD) condition and related mechanisms. The apoptotic process was detected with flow cytometry, and the cell viability was assessed with CCK-8 assay. The expression levels of microRNA (miRNA)-134 were detected with quantitative real-time PCR. Protein expression levels were detect...

Gli3 silencing enhances cyclopamine suppressive effects on ovarian cancer

Ovarian cancer is a leading gynecological malignancy associated with high mortality. Hedgehog signaling has been found to be important for cell proliferation and tumor growth for multiple cancers, including ovarian cancer. The present study showed that the drug cyclopamine, which blocks the hedgehog signaling pathway, could reduce cancer cell growth and proliferation and induce cell apoptosis. ...

MicroRNA - 134 activity in somatostatin interneurons regulates

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Methadone produces prolonged postoperative analgesia.

Neuroprotective Effects of MicroRNA-210 on Hypoxic-Ischemic Encephalopathy

OBJECTIVES To reveal the effect of microRNA-210 on cell apoptosis caused by HIE. METHODS Postnatal day 7 rats after HI injury were intraventricularly injected with microRNA-210 mimic, microRNA-210 inhibitor, or physiological saline. 72 h after the injection, rats were sacrificed and the left hemispheres were collected. The expression level of microRNA-210 was identified by quantitative real-t...